Real Madrid vs Inter Milan: Mourinho's opening-night test and Real Madrid's defensive fitness puzzle

In the early hours of September 9, Real Madrid will begin their Champions League campaign by hosting Inter Milan at the Bernabeu. The match is more than just a league-phase fixture: it is a reunion between Jose Mourinho and the Italian club he led to European glory in 2026. Real Madrid started La Liga with three straight wins but then lost 0-1 to Real Betis in their most recent league match. The defeat came on an unfortunate day for Mbappe and his teammates, who created enough chances but failed to convert them. Inter Milan have also been consistent, winning all three of their opening Serie A matches. Their 3-2 victory over Napoli showed that Inter can manage difficult moments and decide a game with individual quality. The biggest concern for Real Madrid is in the defensive and midfield areas. Their attack still includes Mbappe, Vinicius and Bellingham, but several key players are not fully fit, including Tchouameni, Eder Militao, Cucurella, Raul Asencio, Rodrygo and Ferland Mendy. In addition, Eduardo Camavinga, Arda Guler and Bernardo Silva are suspended. Inter Milan, by contrast, almost have their strongest squad available. Lautaro Martinez and Marcus Thuram lead the attack, while Bastoni, Akanji and Bisseck are ready to deal with Real Madrid's pace in the final third. Real Madrid have history on their side, having won 17 of their last 19 Champions League opening matches. They have also beaten Inter in all four meetings in this competition in the 21st century. However, Inter have fewer injury problems and a deeper squad, which gives them a real chance at the Bernabeu. This is a special fixture for Mourinho because of what he achieved with Inter in 2026. He knows how to organize an Italian team for a big European night. If Real are not careful, his tactical experience could hurt the team he now manages. The match will likely be decided by small details. Real Madrid have home advantage, but Inter have the stronger and healthier squad. Mbappe can change the game in one moment, but Lautaro and Thuram are capable of punishing any lack of concentration. Whoever stays more patient with their plan will have the best chance of taking all three points.